ZFIN Lab: Drummond Lab (2024)

GENOMIC FEATURES ORIGINATING FROM THIS LAB

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The zebrafish pronephros as a model of kidney development.

We are studying the zebrafish pronephros in order to answer questions concerning early patterning events affecting kidney
development, epithelial cell differentiation, the generation of cell polarity, and the development of kidney vasculature. The
zebrafish pronephric kidney provides a simplified model of nephron development and epithelial cell differentiation which is
amenable to genetic analysis. By taking advantage of mutations affecting the pronephros, we are uncovering new aspects of
kidney cell differentiation.

Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:

Djenoune, L., Tomar, R., Dorison, A., Ghobrial, I., Schenk, H., Hegermann, J., Beverly-Staggs, L., Hidalgo-Gonzalez, A., Little, M.H., Drummond, I.A. (2021) Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis. Journal of the American Society of Nephrology : JASN. 32(7):1697-1712

Babich, R., Ulrich, J.C., Ekanayake, E.M.D.V., Massarsky, A., De Silva, P.M.C.S., Manage, P.M., Jackson, B.P., Ferguson, P.L., Di Giulio, R.T., Drummond, I.A., Jayasundara, N. (2020) Kidney developmental effects of metal-herbicide mixtures: Implications for chronic kidney disease of unknown etiology. Environment International. 144:106019

Sugano, Y., Siegfried, H., Merkel, E., Drummond, I.A. (2020) Novel Transgenic Lines to Analyze Renal Glutathione Redox Potential In Vivo. Zebrafish. 17:153-155

Dong, S.S., Zhang, D.N., Zhang, Z.H., Yu, C.G., Liu, Y., Zhao, H.M., Wang, C.Y. (2019) [Ecotoxicological effects of transgenic mCry1Ac maize (BT799) on zebrafish]. Ying yong sheng tai xue bao = The journal of applied ecology. 30:2845-2853

Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51

Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730

Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):

Bergboer, J.G.M., Wyatt, C., Austin-Tse, C., Yaksi, E., Drummond, I.A. (2018) Assaying sensory ciliopathies using calcium biosensor expression in zebrafish ciliated olfactory neurons. Cilia. 7:2

Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887

Lopez-Rivera, E., Liu, Y.P., Verbitsky, M., Anderson, B.R., Capone, V.P., Otto, E.A., Yan, Z., Mitrotti, A., Martino, J., Steers, N.J., Fasel, D.A., Vukojevic, K., Deng, R., Racedo, S.E., Liu, Q., Werth, M., Westland, R., Vivante, A., Makar, G.S., Bodria, M., Sampson, M.G., Gillies, C.E., Vega-Warner, V., Maiorana, M., Petrey, D.S., Honig, B., Lozanovski, V.J., Salomon, R., Heidet, L., Carpentier, W., Gaillard, D., Carrea, A., Gesualdo, L., Cusi, D., Izzi, C., Scolari, F., van Wijk, J.A., Arapovic, A., Saraga-Babic, M., Saraga, M., Kunac, N., Samii, A., McDonald-McGinn, D.M., Crowley, T.B., Zackai, E.H., Drozdz, D., Miklaszewska, M., Tkaczyk, M., Sikora, P., Szczepanska, M., Mizerska-Wasiak, M., Krzemien, G., Szmigielska, A., Zaniew, M., Darlow, J.M., Puri, P., Barton, D., Casolari, E., Furth, S.L., Warady, B.A., Gucev, Z., Hakonarson, H., Flogelova, H., Tasic, V., Latos-Bielenska, A., Materna-Kiryluk, A., Allegri, L., Wong, C.S., Drummond, I.A., D'Agati, V., Imamoto, A., Barasch, J.M., Hildebrandt, F., Kiryluk, K., Lifton, R.P., Morrow, B.E., Jeanpierre, C., Papaioannou, V.E., Ghiggeri, G.M., Gharavi, A.G., Katsanis, N., Sanna-Cherchi, S. (2017) Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. The New England Journal of Medicine. 376(8):742-754

Pu, Y.Z., Liang, L., Fu, A.L., Liu, Y., Sun, L., Li, Q., Wu, D., Sun, M.J., Zhang, Y.G., Zhao, B.Q. (2017) Generation of Alzheimer's Disease Transgenic Zebrafish Expressing Human APP Mutation under Control of Zebrafish appb Promotor. Current Alzheimer research. 14(6):668-679

Olabisi, O., Al-Romaih, K., Henderson, J., Tomar, R., Drummond, I., MacRae, C., Pollak, M. (2016) From man to fish: What can Zebrafish tell us about ApoL1 nephropathy?. Clinical nephrology. 86 (2016)(13):114-118

Liu, Y., Zhang, Y., Tao, S., Guan, Y., Zhang, T., Wang, Z. (2016) Global DNA methylation in gonads of adult zebrafish Danio rerio under bisphenol A exposure. Ecotoxicology and environmental safety. 130:124-132

Johnson, K., Barragan, J., Bashiruddin, S., Smith, C.J., Tyrrell, C., Parsons, M.J., Doris, R., Kucenas, S., Downes, G.B., Velez, C.M., Schneider, C., Sakai, C., Pathak, N., Anderson, K., Stein, R., Devoto, S.H., Mumm, J.S., Barresi, M.J. (2016) Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord. Glia. 64(7):1170-89

Drummond, I.A., Davidson, A.J. (2016) Zebrafish kidney development. Methods in cell biology. 134:391-429

Bizet, A.A., Becker-Heck, A., Ryan, R., Weber, K., Filhol, E., Krug, P., Halbritter, J., Delous, M., Lasbennes, M.C., Linghu, B., Oakeley, E.J., Zarhrate, M., Nitschké, P., Garfa-Traore, M., Serluca, F., Yang, F., Bouwmeester, T., Pinson, L., Cassuto, E., Dubot, P., Elshakhs, N.A., Sahel, J.A., Salomon, R., Drummond, I.A., Gubler, M.C., Antignac, C., Chibout, S., Szustakowski, J.D., Hildebrandt, F., Lorentzen, E., Sailer, A.W., Benmerah, A., Saint-Mezard, P., Saunier, S. (2015) Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nature communications. 6:8666

Ou, C., Zhang, S., Liu, J., Shen, J., Liu, Y., Sun, X., Li, J., Wang, L. (2015) Removal of multi-substituted nitroaromatic pollutants by zero valent iron: a comparison of performance, kinetics, toxicity and mechanisms. Physical chemistry chemical physics : PCCP. 17:22072-8

Kamei, C.N., Liu, Y., Drummond, I.A. (2015) Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury. Journal of visualized experiments : JoVE. (102):e51912

Oltrabella, F., Pietka, G., Ramirez, I.B., Mironov, A., Starborg, T., Drummond, I.A., Hinchliffe, K.A., Lowe, M. (2015) The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule. PLoS Genetics. 11:e1005058

Yeo, N.C., O'Meara, C.C., Bonomo, J.A., Veth, K.N., Tomar, R., Flister, M.J., Drummond, I.A., Bowden, D.W., Freedman, B.I., Lazar, J., Link, B.A., Jacob, H.J. (2015) Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Genome research. 25(1):57-65

Fogelgren, B., Zuo, X., Buonato, J.M., Vasilyev, A., Baek, J.I., Choi, S.Y., Chacon-Heszele, M.F., Palmyre, A., Polgar, N., Drummond, I.A., Park, K.M., Lazzara, M.J., Lipschutz, J.H. (2014) Exocyst Sec10 Protects Renal Tubule Cells from Injury by EGFR/MAPK Activation and Effects on Endocytosis. American journal of physiology. Renal physiology. 307(12):F1334-41

Liu, Y., Asnani, A., Zou, L., Bentley, V.L., Yu, M., Wang, Y., Dellaire, G., Sarkar, K.S., Dai, M., Chen, H.H., Sosnovik, D.E., Shin, J.T., Haber, D.A., Berman, J.N., Chao, W., Peterson, R.T. (2014) Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science Translational Medicine. 6:266ra170

Terashima, A.V., Mudumana, S.P., Drummond, I.A. (2014) Odd skipped related 1 is a negative feedback regulator of Nodal-induced endoderm development. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(12):1571-80

Tomar, R., Mudumana, S.P., Pathak, N., Hukreide, N.A., Drummond, I.A. (2014) osr1 Is Required for Podocyte Development Downstream of wt1a. Journal of the American Society of Nephrology : JASN. 25(11):2539-45

Slaats, G.G., Ghosh, A.K., Falke, L.L., Le Corre, S., Shaltiel, I.A., van de Hoek, G., Klasson, T.D., Stokman, M.F., Logister, I., Verhaar, M.C., Goldschmeding, R., Nguyen, T.Q., Drummond, I.A., Hildebrandt, F., Giles, R.H. (2014) Nephronophthisis-Associated CEP164 Regulates Cell Cycle Progression, Apoptosis and Epithelial-to-Mesenchymal Transition. PLoS Genetics. 10:e1004594

Xu, M., Liu, D., Dong, Z., Wang, X., Wang, X., Liu, Y., Baas, P.W., Liu, M. (2014) Kinesin-12 influences axonal growth during zebrafish neural development. Cytoskeleton (Hoboken, N.J.). 71(10):555-63

Jin, D., Ni, T.T., Sun, J., Wan, H., Amack, J.D., Yu, G., Fleming, J., Chiang, C., Li, W., Papierniak, A., Cheepala, S., Conseil, G., Cole, S.P., Zhou, B., Drummond, I.A., Schuetz, J.D., Malicki, J., Zhong, T.P. (2014) Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nature cell biology. 16(9):841-51

Le Corre, S., Eyre, D., Drummond, I.A. (2014) Modulation of the Secretory Pathway Rescues Zebrafish Polycystic Kidney Disease Pathology. Journal of the American Society of Nephrology : JASN. 25(8):1749-59

Palmyre, A., Lee, J., Ryklin, G., Camarata, T., Selig, M.K., duch*emin, A.L., Nowak, P., Arnaout, M.A., Drummond, I.A., Vasilyev, A. (2014) Collective epithelial migration drives kidney repair after acute injury. PLoS One. 9:e101304

Pathak, N., Austin-Tse, C.A., Liu, Y., Vasilyev, A., Drummond, I.A. (2014) Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. Molecular biology of the cell. 25(12):1836-44

Huang, L.D., Fan, Y.Z., Tian, Y., Yang, Y., Liu, Y., Wang, J., Zhao, W.S., Zhou, W.C., Cheng, X.Y., Cao, P., Lu, X.Y., Yu, Y. (2014) Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations. PLoS One. 9:e97528

Thomas, S., Wright, K.J., Le Corre, S., Micalizzi, A., Romani, M., Abhyankar, A., Saada, J., Perrault, I., Amiel, J., Litzler, J., Filhol, E., Elkhartoufi, N., Kwong, M., Casanova, J.L., Boddaert, N., Baehr, W., Lyonnet, S., Munnich, A., Burglen, L., Chassaing, N., Encha-Ravazi, F., Vekemans, M., Gleeson, J.G., Valente, E.M., Jackson, P.K., Drummond, I.A., Saunier, S., and Attié-Bitach, T. (2014) A hom*ozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. Human Mutation. 35(1):137-46

Lam, P.Y., Kamei, C.N., Mangos, S., Mudumana, S., Liu, Y., and Drummond, I.A. (2013) odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(11):1284-92

Austin-Tse, C., Halbritter, J., Zariwala, M.A., Gilberti, R.M., Gee, H.Y., Hellman, N., Pathak, N., Liu, Y., Panizzi, J.R., Patel-King, R.S., Tritschler, D., Bower, R., O'Toole, E., Porath, J.D., Hurd, T.W., Chaki, M., Diaz, K.A., Kohl, S., Lovric, S., Hwang, D.Y., Braun, D.A., Schueler, M., Airik, R., Otto, E.A., Leigh, M.W., Noone, P.G., Carson, J.L., Davis, S.D., Pittman, J.E., Ferkol, T.W., Atkinson, J.J., Olivier, K.N., Sagel, S.D., Dell, S.D., Rosenfeld, M., Milla, C.E., Loges, N.T., Omran, H., Porter, M.E., King, S.M., Knowles, M.R., Drummond, I.A., and Hildebrandt, F. (2013) Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. American journal of human genetics. 93(4):672-686

Sanna-Cherchi, S., Sampogna, R.V., Papeta, N., Burgess, K.E., Nees, S.N., Perry, B.J., Choi, M., Bodria, M., Liu, Y., Weng, P.L., Lozanovski, V.J., Verbitsky, M., Lugani, F., Sterken, R., Paragas, N., Caridi, G., Carrea, A., Dagnino, M., Materna-Kiryluk, A., Santamaria, G., Murtas, C., Ristoska-Bojkovska, N., Izzi, C., Kacak, N., Bianco, B., Giberti, S., Gigante, M., Piaggio, G., Gesualdo, L., Vukic, D.K., Vukojevic, K., Saraga-Babic, M., Saraga, M., Gucev, Z., Allegri, L., Latos-Bielenska, A., Casu, D., State, M., Scolari, F., Ravazzolo, R., Kiryluk, K., Al-Awqati, Q., D'Agati, V.D., Drummond, I.A., Tasic, V., Lifton, R.P., Ghiggeri, G.M., and Gharavi, A.G. (2013) Mutations in DSTYK and Dominant Urinary Tract Malformations. New. Engl. J. Med.. 369(7):621-9

Zariwala, M.A., Gee, H.Y., Kurkowiak, M., Al-Mutairi, D.A., Leigh, M.W., Hurd, T.W., Hjeij, R., Dell, S.D., Chaki, M., Dougherty, G.W., Adan, M., Spear, P.C., Esteve-Rudd, J., Loges, N.T., Rosenfeld, M., Diaz, K.A., Olbrich, H., Wolf, W.E., Sheridan, E., Batten, T.F., Halbritter, J., Porath, J.D., Kohl, S., Lovric, S., Hwang, D.Y., Pittman, J.E., Burns, K.A., Ferkol, T.W., Sagel, S.D., Olivier, K.N., Morgan, L.C., Werner, C., Raidt, J., Pennekamp, P., Sun, Z., Zhou, W., Airik, R., Natarajan, S., Allen, S.J., Amirav, I., Wieczorek, D., Landwehr, K., Nielsen, K., Schwerk, N., Sertic, J., Köhler, G., Washburn, J., Levy, S., Fan, S., Koerner-Rettberg, C., Amselem, S., Williams, D.S., Mitchell, B.J., Drummond, I.A., Otto, E.A., Omran, H., Knowles, M.R., and Hildebrandt, F. (2013) ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6. American journal of human genetics. 93(2):336-345

Nath, A.K., Roberts, L.D., Liu, Y., Mahon, S.B., Kim, S., Ryu, J.H., Werdich, A., Januzzi, J.L., Boss, G.R., Rockwood, G.A., MacRae, C.A., Brenner, M., Gerszten, R.E., and Peterson, R.T. (2013) Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(5):1928-1938

Drummond, I., and Austin-Tse, C. (2013) Zebrafish cilia. Methods in enzymology. 525:219-244

Jin, S., Sarkar, K.S., Jin, Y.N., Liu, Y., Kokel, D., Van Ham, T.J., Roberts, L.D., Gerszten, R.E., MacRae, C.A., and Peterson, R.T. (2013) An In Vivo Zebrafish Screen Identifies Organophosphate Antidotes with Diverse Mechanisms of Action. Journal of Biomolecular Screening. 18(1):108-115

Manning, D.K., Sergeev, M., van Heesbeen, R.G., Wong, M.D., Oh, J.H., Liu, Y., Henkelman, R.M., Drummond, I., Shah, J.V., and Beier, D.R. (2013) Loss of the ciliary kinase nek8 causes left-right asymmetry defects. Journal of the American Society of Nephrology : JASN. 34(1):100-112

Chaki, M., Airik, R., Ghosh, A.K., Giles, R.H., Chen, R., Slaats, G.G., Wang, H., Hurd, T.W., Zhou, W., Cluckey, A., Gee, H.Y., Ramaswami, G., Hong, C.J., Hamilton, B.A., Cervenka, I., Ganji, R.S., Bryja, V., Arts, H.H., van Reeuwijk, J., Oud, M.M., Letteboer, S.J., Roepman, R., Husson, H., Ibraghimov-Beskrovnaya, O., Yasunaga, T., Walz, G., Eley, L., Sayer, J.A., Schermer, B., Liebau, M.C., Benzing, T., Le Corre, S., Drummond, I., Janssen, S., Allen, S.J., Natarajan, S., O'Toole, J.F., Attanasio, M., Saunier, S., Antignac, C., Koenekoop, R.K., Ren, H., Lopez, I., Nayir, A., Stoetzel, C., Dollfus, H., Massoudi, R., Gleeson, J.G., Andreoli, S.P., Doherty, D.G., Lindstrad, A., Golzio, C., Katsanis, N., Pape, L., Abboud, E.B., Al-Rajhi, A.A., Lewis, R.A., Omran, H., Lee, E.Y., Wang, S., Sekiguchi, J.M., Saunders, R., Johnson, C.A., Garner, E., Vanselow, K., Andersen, J.S., Shlomai, J., Nurnberg, G., Nurnberg, P., Levy, S., Smogorzewska, A., Otto, E.A., and Hildebrandt, F. (2012) Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling. Cell. 150(3):533-548

Zhang, Q., Liu, Q., Austin, C., Drummond, I., and Pierce, E.A. (2012) Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish. Molecular biology of the cell. 23(16):3069-3078

Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Häffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., and Drummond, I.A. (2012) CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature Genetics. 44(6):714-719

Cui, J., Zhang, Z., Bai, W., Zhang, L., He, X., Ma, Y., Liu, Y., and Chai, Z. (2012) Effects of rare earth elements La and Yb on the morphological and functional development of zebrafish embryos. Journal of environmental sciences (China). 24(2):209-213

Vasilyev, A., and Drummond, I.A. (2012) Live imaging kidney development in zebrafish. Methods in molecular biology (Clifton, N.J.). 886:55-70

Vasilyev, A., Liu, Y., Hellman, N., Pathak, N., and Drummond, I.A. (2012) Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros. PLoS One. 7(7):e39992

Rothschild, S.C., Francescatto, L., Drummond, I.A., and Tombes, R.M. (2011) CaMK-II is a PKD2 target that promotes pronephric kidney development and stabilizes cilia. Development (Cambridge, England). 138(16):3387-97

Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8

Zhang, M., Liu, Y., Wang, S.Z., Zhong, W., Liu, B.H., and Tao, H.W. (2011) Functional elimination of excitatory feedforward inputs underlies developmental refinement of visual receptive fields in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(14):5460-5469

Pathak, N., Austin, C.A., and Drummond, I.A. (2011) Tubulin tyrosine ligase like genes TTLL3 and TTLL6 maintain zebrafish cilia structure and motility. The Journal of biological chemistry. 286(13):11685-11695

Chen, L.M., Zhao, J., Musa-Aziz, R., Pelletier, M.F., Drummond, I.A., and Boron, W.F. (2010) Cloning and characterization of a zebrafish hom*ologue of human AQP1: A bifunctional water and gas channel. American journal of physiology. Regulatory, integrative and comparative physiology. 299(5):R1163-R1174

Hellman, N.E., Liu, Y., Merkel, E., Austin, C., Le Corre, S., Beier, D.R., Sun, Z., Sharma, N., Yoder, B.K., and Drummond, I.A. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proceedings of the National Academy of Sciences of the United States of America. 107(43):18499-18504

Cianciolo Cosentino, C., Roman, B.L., Drummond, I.A., and Hukriede, N.A. (2010) Intravenous microinjections of zebrafish larvae to study acute kidney injury. Journal of visualized experiments : JoVE. (42)

Drummond, I.A., and Davidson, A.J. (2010) Chapter 9 - Zebrafish kidney development. Methods in cell biology. 100:233-260

Sussman, C.R., Zhao, J., Plata, C., Lu, J., Daly, C., Angle, N., Dipiero, J., Drummond, I.A., Liang, J.O., Boron, W.F., Romero, M.F., and Chang, M.H. (2009) Cloning, localization and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish. American journal of physiology. Cell physiology. 297(4):C865-C875

Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.Y., Majumdar, A., Zhao, J., Poon, K.L., Kondrychyn, I., Korzh, V., and Drummond, I.A. (2009) Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology. 7(1):e9

Mudumana, S.P., Hentschel, D., Liu, Y., Vasilyev, A., and Drummond, I.A. (2008) odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development (Cambridge, England). 135(20):3355-3367

Möller, C.C., Mangos, S., Drummond, I.A., and Reiser, J. (2008) Expression of trpC1 and trpC6 orthologs in zebrafish. Gene expression patterns : GEP. 8(5):291-296

Insinna, C., Pathak, N., Perkins, B., Drummond, I., and Besharse, J.C. (2008) The hom*odimeric kinesin, Kif17, is essential for vertebrate photoreceptor sensory outer segment development. Developmental Biology. 316(1):160-170

Pathak, N., Obara, T., Mangos, S., Liu, Y., and Drummond, I.A. (2007) The Zebrafish fleer Gene Encodes an Essential Regulator of Cilia Tubulin Polyglutamylation. Molecular biology of the cell. 18(11):4353-4364

Liu, Y., Pathak, N., Kramer-Zucker, A., and Drummond, I.A. (2007) Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development (Cambridge, England). 134(6):1111-1122

Panizzi, J.R., Jessen, J.R., Drummond, I.A., and Solnica-Krezel, L. (2007) New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development (Cambridge, England). 134(5):921-931

Mangos, S., Liu, Y., and Drummond, I.A. (2007) Dynamic expression of the osmosensory channel trpv4 in multiple developing organs in zebrafish. Gene expression patterns : GEP. 7(4):480-484

Smear, M.C., Tao, H.W., Staub, W., Orger, M.B., Gosse, N.J., Liu, Y., Takahashi, K., Poo, M.M., and Baier, H. (2007) Vesicular Glutamate Transport at a Central Synapse Limits the Acuity of Visual Perception in Zebrafish. Neuron. 53(1):65-77

Hinkes, B., Wiggins, R.C., Gbadegesin, R., Vlangos, C.N., Seelow, D., Nurnberg, G., Garg, P., Verma, R., Chaib, H., Hoskins, B.E., Ashraf, S., Becker, C., Hennies, H.C., Goyal, M., Wharram, B.L., Schachter, A.D., Mudumana, S., Drummond, I., Kerjaschki, D., Waldherr, R., Dietrich, A., Ozaltin, F., Bakkaloglu, A., Cleper, R., Basel-Vanagaite, L., Pohl, M., Griebel, M., Tsygin, A.N., Soylu, A., Muller, D., Sorli, C.S., Bunney, T.D., Katan, M., Liu, J., Attanasio, M., O'toole, J.F., Hasselbacher, K., Mucha, B., Otto, E.A., Airik, R., Kispert, A., Kelley, G.G., Smrcka, A.V., Gudermann, T., Holzman, L.B., Nurnberg, P., Hildebrandt, F. (2006) Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nature Genetics. 38(12):1397-1405

Obara, T., Mangos, S., Liu, Y., Zhao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F., Schier, A.F., and Drummond, I.A. (2006) Polycystin-2 Immunolocalization and Function in Zebrafish. Journal of the American Society of Nephrology : JASN. 17(10):2706-2718

Sayer, J.A., Otto, E.A., O'toole, J.F., Nurnberg, G., Kennedy, M.A., Becker, C., Hennies, H.C., Helou, J., Attanasio, M., Fausett, B.V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R.G., Allen, S.J., Wilkinson, C.J., Nigg, E.A., Shou, C., Lillo, C., Williams, D.S., Hoppe, B., Kemper, M.J., Neuhaus, T., Parisi, M.A., Glass, I.A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M.R., and Hildebrandt, F. (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nature Genetics. 38(6):674-681

Liu, Y., and Halloran, M.C. (2005) Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(45):10556-10563

Shmukler, B.E., Kurschat, C.E., Ackermann, G.E., Jiang, L., Zhou, Y., Barut, B., Stuart-Tilley, A.K., Zhao, J., Zon, L.I., Drummond, I.A., Vandorpe, D.H., Paw, B.H., and Alper, S.L. (2005) Zebrafish slc4a2/ae2 Anion Exchanger: cDNA Cloning, Mapping, Functional Characterization, and Localization. American journal of physiology. Renal physiology. 289(4):F835-849

Kramer-Zucker, A.G., Wiessner, S., Jensen, A.M., and Drummond, I.A. (2005) Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Developmental Biology. 285(2):316-329

Bedell, V.M., Yeo, S.Y., Park, K.W., Chung, J., Seth, P., Shivalingappa, V., Zhao, J., Obara, T., Sukhatme, V.P., Drummond, I.A., Li, D.Y., and Ramchandran, R. (2005) roundabout4 is essential for angiogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102(18):6373-6378

Hentschel, D.M., Park, K.M., Cilenti, L., Zervos, A.S., Drummond, I., and Bonventre, J.V. (2005) Acute renal failure in zebrafish: a novel system to study a complex disease. American journal of physiology. Renal physiology. 288(5):F923-F929

Kramer-Zucker, A.G., Olale, F., Haycraft, C.J., Yoder, B.K., Schier, A.F., and Drummond, I.A. (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (Cambridge, England). 132(8):1907-1921

Drummond, I.A. (2005) Kidney Development and Disease in the Zebrafish. Journal of the American Society of Nephrology : JASN. 16(2):299-304

Wolman, M.A., Liu, Y., Tawarayama, H., Shoji, W., and Halloran, M.C. (2004) Repulsion and attraction of axons by Semaphorin3D are mediated by different neuropilins in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(39):8428-8435

Liu, Y., Berndt, J., Su, F., Tawarayama, H., Shoji, W., Kuwada, J.Y., and Halloran, M.C. (2004) Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(2):310-318

Drummond, I.A. (2004) Zebrafish kidney development. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:501-530

Otto, E.A., Schermer, B., Obara, T., O'Toole, J.F., Hiller, K.S., Mueller, A.M., Ruf, R.G., Hoefele, J., Beekmann, F., Landau, D., Foreman, J.W., Goodship, J.A., Strachan, T., Kispert, A., Wolf, M.T., Gagnadoux, M.F., Nivet, H., Antignac, C., Walz, G., Drummond, I.A., Benzing, T., and Hildebrandt, F. (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nature Genetics. 34(4):413-420

Drummond, I. (2003) Making a zebrafish kidney: a tale of two tubes. Trends in cell biology. 13(7):357-365

Liu, S., Lu, W., Obara, T., Kuida, S., Lehoczky, J., Dewar, K., Drummond, I.A., and Beier, D.R. (2002) A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development (Cambridge, England). 129(24):5839-5846

Liu, S., Obara-Ishihara, T., Drummond, I.A., and Beier, D.R. (2002) Characterization of Nek8, the gene mutated in the jck mouse model of polycystic kidney disease. Journal of the American Society of Nephrology : JASN. 13:116A

Serluca, F.C., Drummond, I.A., and Fishman, M.C. (2002) Endothelial signaling in kidney morphogenesis. A role for hemodynamic forces. Current biology : CB. 12(6):492-497

Drummond, I. (2002) The pronephros. Results and problems in cell differentiation. 40:322-345

Majumdar, A. and Drummond, I.A. (2000) The zebrafish floating head mutant demonstrates podocytes play an important role in directing glomerular differentiation. Developmental Biology. 222(1):147-157

Drummond, I.A (2000) The zebrafish pronephros: a genetic system for studies of kidney development. Pediatric nephrology (Berlin, Germany). 14(5):428-435

Majumdar, A., Lun, K., Brand, M., and Drummond, I.A. (2000) Zebrafish no isthmus reveals a role for pax2.1 in tubule differentiation and patterning events in the pronephric primordia. Development (Cambridge, England). 127(10):2089-2098

Liu, A., Majumdar, A., Schauerte, H.E., Haffter, P., and Drummond, I.A. (2000) Zebrafish wnt4b expression in the floor plate is altered in sonic hedgehog and gli-2 mutants. Mechanisms of Development. 91(1-2):409-413

Majumdar, A. and Drummond, I.A. (1999) Podocyte differentiation in the absence of endothelial cells as revealed in the zebrafish avascular mutant, cloche. Developmental genetics. 24(3-4):220-229

Drummond, I.A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Stemple, D.L., Zwartkruis, F., Rangini, Z., Driever, W., and Fishman, M.C. (1998) Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (Cambridge, England). 125:4655-4667

Drummond, I.A., Rohwer-Nutter, P., and Sukhatme, V.P. (1994) The zebrafish egr1 gene encodes a highly conserved, zinc-finger transcriptional regulator. DNA and cell biology. 13:1047-1055